Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024606 | 0.99 | AGTR1 (0.47) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9024858 | 0.98 | AGTR1 (0.46) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9023830 | 0.85 | AGTR1 (0.46) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9024201 | 0.80 | PTGS2 (0.45) | AGTR1AGTR2PTGS2 | |
| Acetic Acid SCHEMBL9024545 | 0.80 | AGTR1 (0.44) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| Water SCHEMBL9024199 | 0.79 | PTGS2 (0.44) | AGTR1AGTR2PTGS2 | |
| SCHEMBL9024560 | 0.79 | AGTR2 (0.40) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9024009 | 0.79 | AGTR2 (0.41) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9496862 | 0.78 | AGTR1 (0.61) | AGTR1AGTR2 | |
| SCHEMBL9024187 | 0.78 | PTGS2 (0.37) | AGTR1AGTR2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611368-B1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PROD (US) | 1996-02-07 | — | — | EP | disclosed |
| EP-0611368-A1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSINE II ANTAGONISTS. | AMERICAN HOME PROD (US) | 1994-08-24 | — | — | EP | disclosed |
| US-5336677-A | ANTAGONIST OF ANGIOTENSIN II | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-08-09 | — | — | US | disclosed |
| WO-1993008169-A1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSINE II ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-29 | — | — | WO | disclosed |