Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8536313 | 0.81 | HCAR2 (0.43) | HCAR2MEN1LMNAKMT2A | |
| SCHEMBL9025999 | 0.81 | PDE4D (0.53) | KDM4EMEN1KMT2A | |
| SCHEMBL9037584 | 0.81 | HCAR2 (0.36) | HCAR2MEN1LMNAKMT2A | |
| SCHEMBL9025654 | 0.81 | HCAR2 (0.40) | KDM4EHCAR2LMNA | |
| SCHEMBL9026160 | 0.77 | HCAR2 (0.37) | KDM4EHCAR2 | |
| SCHEMBL9026702 | 0.77 | NPC1 (0.44) | — | |
| SCHEMBL9026200 | 0.75 | CHRNB2 (0.38) | HCAR2 | |
| SCHEMBL14556096 | 0.74 | KDM4E (0.57) | KDM4EMEN1LMNAKMT2A | |
| SCHEMBL9024908 | 0.74 | HCAR2 (0.31) | HCAR2 | |
| SCHEMBL9027062 | 0.71 | HCAR2 (0.33) | HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0725783-A1 | 2-(PYRAZOL-3-YL)CARBAPENEM DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1996-08-14 | — | — | EP | disclosed |
| WO-1995011905-A1 | 2-(PYRAZOL-3-YL)CARBAPENEM DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1995-05-04 | — | — | WO | disclosed |