Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026458 | 0.90 | KDM4E (0.41) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL9025501 | 0.86 | HPGD (0.50) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL9025085 | 0.85 | RAB9A (0.43) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL9216010 | 0.85 | RAB9A (0.42) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL9026001 | 0.85 | KMT2A (0.42) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL9024885 | 0.85 | KDM4E (0.43) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL9025551 | 0.85 | KDM4E (0.43) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL9032003 | 0.80 | DHFR (0.42) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL9025420 | 0.79 | KDM4E (0.41) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL9026121 | 0.79 | HRH3 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |