Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 4/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026325 | 0.88 | CYP11B2 (0.46) | PDE4ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL9025499 | 0.84 | PDE4A (0.43) | PDE4ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL9025452 | 0.83 | CYP19A1 (0.38) | NPC1SMN1; SMN2MAPTAAK1KDM4E | |
| SCHEMBL9026850 | 0.80 | KDM4E (0.50) | NPC1SMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL9025501 | 0.80 | HPGD (0.50) | NPC1SMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL9025551 | 0.79 | KDM4E (0.43) | NPC1SMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL9025085 | 0.79 | RAB9A (0.43) | NPC1SMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL9026001 | 0.79 | KMT2A (0.42) | NPC1SMN1; SMN2KDM4EALDH1A1TSHR | |
| SCHEMBL9216010 | 0.79 | RAB9A (0.42) | NPC1SMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL9024885 | 0.79 | KDM4E (0.43) | NPC1SMN1; SMN2KDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |