Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 2/20 | 0.41 |
| ▸ | CCKBR | P32239 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026403 | 1.00 | KDM4E (0.43) | KDM4EHPGDHSD17B10GPR84CMA1 | |
| SCHEMBL9026142 | 0.80 | CCKBR (0.38) | KDM4EHPGDHSD17B10GPR84CMA1 | |
| SCHEMBL9848971 | 0.80 | CCKBR (0.38) | KDM4EHPGDHSD17B10GPR84CMA1 | |
| SCHEMBL9025971 | 0.80 | CCKBR (0.38) | KDM4EHPGDHSD17B10GPR84CMA1 | |
| SCHEMBL9027168 | 0.79 | MAPT (0.51) | KDM4EHPGDHSD17B10CCKBRALDH1A1 | |
| SCHEMBL9027690 | 0.79 | MAPT (0.51) | KDM4EHPGDHSD17B10CCKBRALDH1A1 | |
| SCHEMBL10466586 | 0.75 | GPR84 (0.46) | KDM4EGPR84CMA1CCKBRALDH1A1 | |
| SCHEMBL10467137 | 0.72 | HDAC3 (0.48) | KDM4EHPGDHSD17B10GPR84CMA1 | |
| SCHEMBL5018864 | 0.67 | GPR84 (0.67) | KDM4EHPGDHSD17B10GPR84ALDH1A1 | |
| SCHEMBL10468191 | 0.67 | GPR84 (0.57) | KDM4EGPR84CMA1CCKBRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-B1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMA CO LTD (JP) | 1996-11-27 | — | — | EP | disclosed |
| US-5238938-A | Nephrosis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | disclosed |