Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.58 |
| ▸ | DRD2 | P14416 | 6/20 | 0.58 |
| ▸ | DRD3 | P35462 | 3/20 | 0.58 |
| ▸ | HTR2C | P28335 | 3/20 | 0.58 |
| ▸ | HTR2B | P41595 | 3/20 | 0.58 |
| ▸ | DRD4 | P21917 | 2/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 4/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026950 | 0.83 | HTR1A (0.51) | HTR1ADRD2DRD3HTR2CDRD4 | |
| SCHEMBL9026121 | 0.74 | HRH3 (0.51) | DRD2DRD3SLC6A2SLC6A4 | |
| SCHEMBL9161589 | 0.73 | HTR1A (0.70) | HTR1ADRD2HTR2CHTR2AHTR7 | |
| SCHEMBL10733089 | 0.73 | ADRA1D (0.84) | HTR1ADRD2DRD3HTR2CADRA1D | |
| SCHEMBL10864396 | 0.72 | HTR1A (0.60) | HTR1ADRD2DRD3HTR2CHTR7 | |
| SCHEMBL6357014 | 0.72 | DRD3 (0.94) | HTR1ADRD2DRD3HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL10865028 | 0.72 | HTR1A (0.59) | HTR1ADRD2DRD3HTR2CHTR7 | |
| Hydrochloric Acid SCHEMBL9082274 | 0.71 | DRD3 (0.93) | HTR1ADRD2DRD3HTR2CHTR2B | |
| SCHEMBL10864794 | 0.71 | MEN1 (0.59) | HTR1ADRD2HTR2CHTR7 | |
| SCHEMBL5439597 | 0.70 | ADRA1D (0.87) | HTR1ADRD2DRD3HTR2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |