SCHEMBL9027205

SCHEMBL9027205

C=CCOC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)C[C@H]1Cc1cc[n+]([O-])cc1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.31
SIGMAR1 Q99720 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9026864 0.89 SIGMAR1 (0.32) SIGMAR1
SCHEMBL8832613 0.88 SNCA (0.33) CYP19A1SIGMAR1
SCHEMBL9026576 0.88 SNCA (0.33) CYP19A1SIGMAR1
SCHEMBL8833008 0.84 SIGMAR1 (0.32) CYP19A1SIGMAR1
SCHEMBL8833618 0.83 CHRNB2 (0.35) CYP19A1SIGMAR1
SCHEMBL8833108 0.83 CETP (0.33) CYP19A1SIGMAR1
SCHEMBL9037600 0.82 VHL (0.32) CYP19A1SIGMAR1
SCHEMBL9037597 0.82 VHL (0.32) CYP19A1SIGMAR1
SCHEMBL9027814 0.81 OPRM1 (0.31) SIGMAR1
SCHEMBL9027810 0.81 OPRM1 (0.31) SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0722447-A1 3-PYRROLIDINYLTHIO-CARBAPENEM DERIVATIVES AND THEIR ANTIMICROBAL ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-07-24 EP disclosed
WO-1995010520-A1 3-PYRROLIDINYLTHIO-CARBAPENEM DERIVATIVES AND THEIR ANTIMICROBAL ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1995-04-20 WO disclosed