Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 5/20 | 0.63 |
| ▸ | HTR2C | P28335 | 3/20 | 0.57 |
| ▸ | IDH2 | P48735 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | MAP3K12 | Q12852 | 6/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901243 | 0.85 | KARS1 (0.59) | KARS1HTR2CSYK | |
| SCHEMBL901538 | 0.82 | KARS1 (0.60) | KARS1HTR2CCDK9 | |
| SCHEMBL902090 | 0.78 | KARS1 (0.55) | KARS1IDH2SYK | |
| SCHEMBL901925 | 0.77 | KARS1 (0.67) | KARS1HTR2CSYKMAP3K12 | |
| SCHEMBL901727 | 0.77 | KARS1 (1.00) | KARS1HTR2CSYKMAP3K12 | |
| SCHEMBL902609 | 0.76 | HTR2C (0.44) | KARS1HTR2C | |
| SCHEMBL901740 | 0.75 | KARS1 (1.00) | KARS1SYKMAP3K12 | |
| SCHEMBL902909 | 0.75 | KARS1 (0.63) | KARS1IDH2SYK | |
| SCHEMBL186156 | 0.74 | HTR2C (1.00) | HTR2CSOS1 | |
| SCHEMBL12469913 | 0.74 | HTR2C (0.50) | KARS1HTR2CSOS1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |