Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 2/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 5/20 | 0.44 |
| ▸ | JAK3 | P52333 | 5/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902272 | 0.88 | SYK (0.53) | KARS1SYKWNT3A | |
| SCHEMBL901665 | 0.87 | KARS1 (0.53) | KARS1 | |
| SCHEMBL902839 | 0.86 | SYK (0.60) | KARS1SYKJAK2JAK3PTK2 | |
| SCHEMBL902983 | 0.84 | KARS1 (0.64) | KARS1GPR119SYKJAK2JAK3 | |
| SCHEMBL1705277 | 0.83 | JAK2 (0.44) | GPR119SYKJAK2JAK3PTK2 | |
| SCHEMBL1704340 | 0.82 | KARS1 (0.64) | KARS1GPR119 | |
| SCHEMBL1705279 | 0.81 | GRM1 (0.47) | KARS1WNT3A | |
| SCHEMBL901734 | 0.79 | HTT (0.46) | GPR119JAK2JAK3PTK2HPGDS | |
| SCHEMBL902750 | 0.77 | KARS1 (0.64) | KARS1 | |
| SCHEMBL901929 | 0.75 | KARS1 (0.55) | KARS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |