Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 15/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | HTR7 | P34969 | 2/20 | 0.57 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.54 |
| ▸ | PRKCI | P41743 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902600 | 0.86 | KARS1 (1.00) | KARS1 | |
| SCHEMBL901876 | 0.83 | KARS1 (0.71) | KARS1CAMK2D | |
| SCHEMBL901727 | 0.81 | KARS1 (1.00) | KARS1HTR1AHTR7CAMK2DCHEK1 | |
| SCHEMBL1704207 | 0.79 | KARS1 (0.66) | KARS1HTR1AHTR7CAMK2D | |
| SCHEMBL902750 | 0.78 | KARS1 (0.64) | KARS1 | |
| SCHEMBL902983 | 0.78 | KARS1 (0.64) | KARS1 | |
| SCHEMBL901538 | 0.75 | KARS1 (0.60) | KARS1 | |
| SCHEMBL1704397 | 0.75 | KARS1 (0.77) | KARS1 | |
| SCHEMBL1704491 | 0.74 | KARS1 (0.70) | KARS1 | |
| SCHEMBL1704214 | 0.73 | KARS1 (0.77) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |