Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028002 | 0.83 | KDM4E (0.37) | KDM4EMEN1KMT2APTGS1SRD5A1 | |
| SCHEMBL9027573 | 0.83 | KDM4E (0.34) | KDM4EPTGS1ALDH1A1TSHRMAPT | |
| SCHEMBL9026764 | 0.82 | KDM4E (0.39) | KDM4EMEN1KMT2APTGS1SRD5A1 | |
| SCHEMBL7734483 | 0.77 | ALOX5 (0.32) | KDM4EALDH1A1MAPTHPGDALOX5 | |
| SCHEMBL8369415 | 0.75 | PTGS1 (0.46) | KDM4EMEN1KMT2APTGS1SRD5A1 | |
| SCHEMBL7525731 | 0.74 | VCAM1 (0.39) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL9028145 | 0.73 | KDM4E (0.35) | KDM4EALDH1A1LMNASMN1; SMN2TSHR | |
| SCHEMBL9028534 | 0.73 | HSD17B10 (0.37) | KDM4EALDH1A1LMNAHSD17B10MAPT | |
| SCHEMBL7729839 | 0.72 | LIG1 (0.34) | KDM4EMEN1KMT2APTGS1ALDH1A1 | |
| SCHEMBL7520741 | 0.72 | KDM4E (0.39) | KDM4EMEN1KMT2APTGS1SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |