Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | PTPRB | P23467 | 1/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.35 |
| ▸ | OGG1 | O15527 | 1/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ESRRA | P11474 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7525731 | 0.92 | VCAM1 (0.39) | GPR174VCAM1L3MBTL1ALDH1A1ACHE | |
| SCHEMBL9028634 | 0.83 | KAT6A (0.36) | HSD17B10HPGDKAT6AHTTKDM4E | |
| SCHEMBL6768542 | 0.82 | BACE1 (0.42) | HSD17B10HPGDHTTKDM4ETP53 | |
| SCHEMBL9028277 | 0.79 | CYP2C9 (0.47) | HSD17B10HPGDPTPRBKAT6AHTT | |
| SCHEMBL9028543 | 0.77 | KDM4E (0.38) | HSD17B10HPGDHTTKDM4ETP53 | |
| SCHEMBL7523719 | 0.73 | VCAM1 (0.38) | TP53MAPTVCAM1NPC1LMNA | |
| SCHEMBL6764077 | 0.73 | HTT (0.45) | HSD17B10HPGDHTTKDM4ETP53 | |
| SCHEMBL9027992 | 0.73 | KDM4E (0.36) | HSD17B10HPGDHTTKDM4EGAA | |
| SCHEMBL7734483 | 0.73 | ALOX5 (0.32) | HPGDKDM4EMAPTALDH1A1 | |
| SCHEMBL6308039 | 0.72 | BACE1 (0.47) | KDM4ETP53MAPTVCAM1ESRRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |