Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028418 | 0.92 | HTR1A (0.47) | MAOAMAOBHTR1AADRA1DADRA1A | |
| SCHEMBL9026824 | 0.80 | IMPDH2 (0.50) | KMT2APOLBKDM4EHPGDHSD17B10 | |
| SCHEMBL27196389 | 0.75 | HTR1A (0.47) | MAOAMAOBHTR1AADRA1DADRA1A | |
| SCHEMBL9026884 | 0.74 | PDE4D (0.46) | HTR1AADRA1DADRA1AADRA1BPDE4A | |
| SCHEMBL10110908 | 0.74 | HTR1A (0.43) | MAOAMAOBHTR1AADRA1DADRA1A | |
| SCHEMBL1506959 | 0.73 | HTR1A (0.53) | MAOAMAOBHTR1AADRA1DADRA1A | |
| SCHEMBL12600028 | 0.72 | HTR1A (0.53) | MAOAMAOBHTR1AADRA1DADRA1A | |
| SCHEMBL9027983 | 0.71 | PDE4D (0.40) | MAOAMAOBHTR1AADRA1DADRA1A | |
| SCHEMBL9026519 | 0.71 | TSHR (0.46) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL10641796 | 0.70 | MAOA (0.57) | MAOAMAOBHTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558950-B1 | 3-aryl-glycidic ester derivatives and process for their preparation | PHARMACIA SPA (IT) | 1996-12-04 | — | — | EP | claimed |
| EP-0558950-A1 | 3-aryl-glycidic ester derivatives and process for their preparation | PHARMACIA S.p.A. (IT) | 1993-09-08 | — | — | EP | claimed |
| EP-0558950-B1 | 3-aryl-glycidic ester derivatives and process for their preparation | PHARMACIA SPA (IT) | 1996-12-04 | — | — | EP | disclosed |
| US-5436235-A | 3-aryl-glycidic ester derivatives | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-07-25 | — | — | US | disclosed |
| EP-0558950-A1 | 3-aryl-glycidic ester derivatives and process for their preparation | PHARMACIA S.p.A. (IT) | 1993-09-08 | — | — | EP | disclosed |