Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | PKLR | P30613 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704350 | 0.92 | KARS1 (0.47) | KARS1GSK3B | |
| SCHEMBL1704623 | 0.90 | KARS1 (0.60) | KARS1GSK3B | |
| SCHEMBL1704534 | 0.90 | KARS1 (0.52) | KARS1 | |
| SCHEMBL901995 | 0.89 | KARS1 (0.60) | KARS1 | |
| SCHEMBL1704596 | 0.82 | KARS1 (0.48) | KARS1 | |
| SCHEMBL1704302 | 0.82 | KARS1 (0.55) | KARS1 | |
| SCHEMBL1704426 | 0.79 | KARS1 (0.63) | KARS1 | |
| SCHEMBL1704272 | 0.78 | KARS1 (0.74) | KARS1 | |
| SCHEMBL902092 | 0.78 | KARS1 (0.68) | KARS1 | |
| SCHEMBL1704342 | 0.78 | KARS1 (0.71) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |