Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.60 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704534 | 0.90 | KARS1 (0.52) | KARS1LMNAMTORSMG1THRB | |
| SCHEMBL1704302 | 0.90 | KARS1 (0.55) | KARS1 | |
| SCHEMBL902811 | 0.89 | KARS1 (0.51) | KARS1 | |
| SCHEMBL1704342 | 0.89 | KARS1 (0.71) | KARS1 | |
| SCHEMBL1704272 | 0.86 | KARS1 (0.74) | KARS1BRAF | |
| SCHEMBL902003 | 0.85 | KARS1 (0.61) | KARS1LMNASMG1 | |
| SCHEMBL901421 | 0.85 | KARS1 (0.82) | KARS1 | |
| SCHEMBL901757 | 0.85 | KARS1 (0.66) | KARS1BRAF | |
| SCHEMBL1704693 | 0.83 | KARS1 (0.59) | KARS1BRAFSMG1 | |
| SCHEMBL902036 | 0.82 | KARS1 (0.81) | KARS1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |