Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704596 | 0.91 | KARS1 (0.48) | KARS1KDM4ESYK | |
| SCHEMBL901995 | 0.90 | KARS1 (0.60) | KARS1THRBLMNAMTORSMG1 | |
| SCHEMBL902811 | 0.90 | KARS1 (0.51) | KARS1 | |
| SCHEMBL1704426 | 0.89 | KARS1 (0.63) | KARS1KDM4ETHRBLMNATSHR | |
| SCHEMBL902092 | 0.87 | KARS1 (0.68) | KARS1TSHR | |
| SCHEMBL1704302 | 0.82 | KARS1 (0.55) | KARS1SYK | |
| SCHEMBL1704350 | 0.81 | KARS1 (0.47) | KARS1MTORSMG1SYK | |
| SCHEMBL1704272 | 0.80 | KARS1 (0.74) | KARS1 | |
| SCHEMBL1704342 | 0.80 | KARS1 (0.71) | KARS1 | |
| SCHEMBL901757 | 0.79 | KARS1 (0.66) | KARS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |