Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.56 |
| ▸ | RAB9A | P51151 | 11/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.54 |
| ▸ | RELA | Q04206 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.51 |
| ▸ | TUBB | P07437 | 5/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23911673 | 0.80 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL29077256 | 0.79 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2GAAKMT2A | |
| SCHEMBL4907998 | 0.77 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2GAAKMT2A | |
| SCHEMBL23911668 | 0.77 | CYP1A2 (0.44) | NPC1MAPK1MAPTALDH1A1HSD17B10 | |
| SCHEMBL28869666 | 0.75 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2GAAKMT2A | |
| SCHEMBL18978020 | 0.75 | TUBB4A (0.57) | NPC1RAB9ASMN1; SMN2GAAKMT2A | |
| SCHEMBL3767872 | 0.72 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2GAAKMT2A | |
| SCHEMBL3770905 | 0.71 | NR1H4 (0.65) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28642673 | 0.70 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2GAAKMT2A | |
| SCHEMBL18920485 | 0.69 | ALDH1A1 (0.48) | NPC1RAB9ASMN1; SMN2GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2703392-B1 | 5-MEMBERED RING AROMATIC HETEROCYCLIC DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY | SHIONOGI & CO (JP) | 2017-06-14 | — | — | EP | disclosed |
| US-8916594-B2 | 5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2014-12-23 | — | — | US | disclosed |
| US-8916594-B2 | 5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2014-12-23 | — | — | US | disclosed |
| EP-2703392-A1 | 5-MEMBERED RING AROMATIC HETEROCYCLIC DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY | Shionogi & Co., Ltd. (JP) | 2014-03-05 | — | — | EP | disclosed |
| US-20140051862-A1 | 5-MEMBERED RING HETEROAROMATIC DERIVATIVES HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2014-02-20 | — | — | US | disclosed |
| EP-0667865-B1 | OXA- AND THIADIAZOLE DERIVATIVES USED AS INSECTICIDES AND FUNGICIDES | ZENECA LTD (GB) | 1996-12-11 | — | — | EP | disclosed |
| EP-0667865-A1 | OXA- AND THIADIAZOLE DERIVATIVES USED AS INSECTICIDES AND FUNGICIDES. | ZENECA LTD (GB) | 1995-08-23 | — | — | EP | disclosed |
| US-5438066-A | Fungicide, insecticide, miticide and pesticide | ZENECA LIMITED (GB) | 1995-08-01 | — | — | US | disclosed |
| CN-1090848-A | Oxadiazole and thiadiazoles derivative | ZENECA LTD (GB) | 1994-08-17 | — | — | CN | disclosed |
| WO-1994010159-A1 | OXA- AND THIADIAZOLE DERIVATIVES USED AS INSECTICIDES AND FUNGICIDES | ZENECA LIMITED (GB) | 1994-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051862-A1 | 5-MEMBERED RING HETEROAROMATIC DERIVATIVES HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY | NPY5R, NPY1R, NPY2R | NPC1 4606/4885RAB9A 2694/4885SMN1; SMN2 4657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.