Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.66 |
| ▸ | RAB9A | P51151 | 7/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12660084 | 0.82 | NPC1 (0.62) | NPC1SMN1; SMN2RAB9AMEN1CYP1A2 | |
| SCHEMBL23911673 | 0.80 | SMN1; SMN2 (0.53) | NPC1SMN1; SMN2RAB9AMEN1CYP1A2 | |
| SCHEMBL1544710 | 0.79 | SMN1; SMN2 (0.55) | NPC1SMN1; SMN2RAB9AMEN1CYP1A2 | |
| SCHEMBL8016715 | 0.78 | RAB9A (0.53) | NPC1SMN1; SMN2RAB9AMEN1CYP1A2 | |
| SCHEMBL9028248 | 0.77 | NPC1 (0.56) | NPC1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL15479735 | 0.77 | HTT (0.57) | NPC1SMN1; SMN2RAB9AMEN1CYP1A2 | |
| SCHEMBL14818742 | 0.77 | MAPT (0.58) | NPC1SMN1; SMN2RAB9AMEN1CYP1A2 | |
| SCHEMBL21485722 | 0.75 | NPC1 (0.77) | NPC1SMN1; SMN2RAB9AMEN1CYP1A2 | |
| SCHEMBL28869647 | 0.75 | SMN1; SMN2 (0.54) | NPC1SMN1; SMN2RAB9AMEN1CYP1A2 | |
| SCHEMBL13930879 | 0.75 | RAB9A (1.00) | NPC1SMN1; SMN2RAB9AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058314-A1 | Novel dicarboxylic acid derivatives with pharmaceutical properties | BAYER AKTIENGESELLSCHAFT | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058314-A1 | Novel dicarboxylic acid derivatives with pharmaceutical properties | PC, GOT2, SDHA | NPC1 965/4885SMN1; SMN2 3741/4885RAB9A 3540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.