Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027877 | 0.91 | HRH1 (0.40) | HRH1TACR1 | |
| SCHEMBL9027955 | 0.86 | ALDH1A1 (0.39) | CASP1TSHRALDH1A1HTTMEN1 | |
| SCHEMBL8448858 | 0.80 | TSHR (0.35) | CASP1TSHRHRH1L3MBTL1ALDH1A1 | |
| SCHEMBL27412215 | 0.80 | PKM (0.39) | HRH1L3MBTL1ALDH1A1HTTMEN1 | |
| SCHEMBL9028321 | 0.80 | MAPT (0.39) | CASP1TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL27405658 | 0.80 | L3MBTL1 (0.43) | HRH1L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL9028215 | 0.79 | HRH1 (0.46) | HRH1ALDH1A1TACR1 | |
| SCHEMBL27401370 | 0.78 | L3MBTL1 (0.37) | HRH1L3MBTL1ALDH1A1HTTMEN1 | |
| SCHEMBL9028269 | 0.78 | MEN1 (0.39) | CASP1TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL9028585 | 0.78 | TACR2 (0.45) | HRH1ALDH1A1MEN1KMT2ATACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563133-A | NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0714891-A1 | Heterocyclic tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-06-05 | — | — | EP | disclosed |