Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | HPN | P05981 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10951644 | 0.80 | CYP2C9 (0.53) | CYP2C9CYP2C19CYP1A2CA2CA1 | |
| SCHEMBL9028534 | 0.79 | HSD17B10 (0.37) | ALDH1A1HTTL3MBTL1MAPTHSD17B10 | |
| SCHEMBL25260431 | 0.78 | CYP2C9 (0.50) | CYP2C9CYP2C19CYP1A2CA2CA1 | |
| SCHEMBL8877323 | 0.76 | HPGD (0.46) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL10954074 | 0.74 | CA2 (0.77) | CYP2C9CYP2C19CYP1A2CA2CA1 | |
| SCHEMBL7525731 | 0.74 | VCAM1 (0.39) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL28027411 | 0.73 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL9028293 | 0.72 | CYP2C9 (0.52) | CYP2C9CYP2C19CYP1A2CA2CA1 | |
| SCHEMBL5706719 | 0.72 | CYP1A2 (0.52) | CYP2C9CYP2C19CYP1A2CA2CA1 | |
| SCHEMBL11170010 | 0.70 | CYP2C9 (0.53) | CYP2C9CYP2C19CYP1A2CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |