Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | FASN | P49327 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.34 |
| ▸ | CSF1R | P07333 | 3/20 | 0.34 |
| ▸ | PIM1 | P11309 | 3/20 | 0.34 |
| ▸ | CLK2 | P49760 | 3/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.34 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | INSR | P06213 | 2/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10189555 | 0.73 | SCD (0.54) | CYP3A4CYP2C9 | |
| SCHEMBL902542 | 0.70 | PDE7A (0.37) | CYP3A4CYP2C9APPFASNMAP4K4 | |
| SCHEMBL902654 | 0.68 | FASN (0.40) | FASNCHEK1DGAT1RAF1 | |
| SCHEMBL902790 | 0.68 | DGAT1 (0.51) | DGAT1 | |
| SCHEMBL902210 | 0.68 | PKN1 (0.60) | FASNDGAT1RAF1 | |
| SCHEMBL19803789 | 0.68 | CYP3A4 (0.52) | CYP3A4CYP2C9APP | |
| SCHEMBL11891678 | 0.68 | CYP3A4 (0.52) | CYP3A4CYP2C9APPDHODH | |
| SCHEMBL18411545 | 0.67 | CYP3A4 (0.57) | CYP3A4CYP2C9APPDHODHRAF1 | |
| SCHEMBL20663895 | 0.67 | CYP3A4 (0.51) | CYP3A4CYP2C9APPDHODH | |
| SCHEMBL18458513 | 0.67 | CYP3A4 (0.57) | CYP3A4CYP2C9APPDHODHRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |