Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.66 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.66 |
| ▸ | TLR7 | Q9NYK1 | 15/20 | 0.58 |
| ▸ | PDE4A | P27815 | 2/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043935 | 0.96 | KMT2A (0.65) | KMT2AAGTR1AGTR2TLR7PDE4A | |
| SCHEMBL9028574 | 0.92 | KMT2A (0.62) | KMT2AAGTR1AGTR2TLR7PDE4A | |
| SCHEMBL8347167 | 0.88 | AGTR2 (0.61) | KMT2AAGTR1AGTR2TLR7PDE4A | |
| SCHEMBL9029790 | 0.87 | KMT2A (0.61) | KMT2AAGTR1AGTR2TLR7 | |
| SCHEMBL29109918 | 0.86 | AGTR1 (0.59) | KMT2AAGTR1AGTR2TLR7 | |
| SCHEMBL9872947 | 0.76 | TLR7 (0.56) | TLR7 | |
| SCHEMBL13968058 | 0.74 | TLR7 (0.77) | TLR7 | |
| SCHEMBL21555503 | 0.73 | TLR7 (0.68) | TLR7 | |
| SCHEMBL30267787 | 0.73 | TLR7 (1.00) | TLR7 | |
| SCHEMBL16487370 | 0.73 | TLR7 (1.00) | TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609289-B1 | IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | UPJOHN CO (US) | 1996-07-17 | — | — | EP | disclosed |
| US-5442062-A | Treating hypertension, congestive heart failure | THE UPJOHN COMPANY (US) | 1995-08-15 | — | — | US | disclosed |
| EP-0609289-A1 | IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. | UPJOHN CO (US) | 1994-08-10 | — | — | EP | disclosed |
| EP-0540209-A1 | Imidazole derivatives and pharmaceutical compositions containing the same | THE UPJOHN COMPANY (US) | 1993-05-05 | — | — | EP | disclosed |
| WO-1993008193-A1 | IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | THE UPJOHN COMPANY (US) | 1993-04-29 | — | — | WO | disclosed |