Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylsulfane SCHEMBL28287035 | 0.90 | HPGD (0.52) | HPGDALDH1A1BCL2MCL1CA2 | |
| Diphenylsulfane SCHEMBL28495635 | 0.81 | CA2 (0.73) | HPGDALDH1A1BCL2MCL1CA2 | |
| Diphenylsulfane SCHEMBL28510403 | 0.81 | ALDH1A1 (0.58) | HPGDALDH1A1BCL2MCL1MAOA | |
| Diphenylsulfane SCHEMBL31544646 | 0.79 | ALDH1A1 (0.46) | HPGDALDH1A1BCL2MCL1CA2 | |
| Diphenylsulfane SCHEMBL7024955 | 0.78 | HPGD (0.62) | HPGDALDH1A1BCL2MCL1MAOA | |
| Diphenylsulfane SCHEMBL6843735 | 0.78 | HPGD (0.62) | HPGDALDH1A1BCL2MCL1MAOA | |
| Diphenylsulfane SCHEMBL19056221 | 0.78 | HPGD (0.62) | HPGDALDH1A1BCL2MCL1MAOA | |
| Diphenylsulfane SCHEMBL27500092 | 0.78 | HPGD (0.54) | HPGDALDH1A1MAOAMAOBSIRT1 | |
| Diphenylsulfane SCHEMBL28332331 | 0.78 | HPGD (0.60) | HPGDALDH1A1BCL2MCL1MAOA | |
| Diphenylsulfane SCHEMBL452 | 0.78 | HPGD (0.60) | HPGDALDH1A1BCL2MCL1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738273-A1 | MONOHYDRATE OF (E)-2'-DEOXY-2'-(FLUOROMETHYLENE)CYTIDINE | MERRELL PHARMACEUTICALS INC. (US) | 1996-10-23 | — | — | EP | disclosed |
| WO-1996001638-A1 | METHOD OF TREATING A NEOPLASTIC DISEASE STATE BY CONJUNCTIVE THERAPY WITH 2'-FLUOROMETHYLIDENE DERIVATIVES AND RADIATION OR CHEMOTHERAPY | HOECHST MARION ROUSSEL, INC. (US) | 1996-01-25 | — | — | WO | disclosed |
| WO-1995018815-A1 | MONOHYDRATE OF (E)-2'-DEOXY-2'-(FLUOROMETHYLENE)CYTIDINE | MERRELL PHARMACEUTICALS INC. (US) | 1995-07-13 | — | — | WO | disclosed |
| EP-0640092-A1 | A PROCESS FOR THE PREPARATION OF RIBONUCLEOTIDE REDUCTASE INHIBITORS. | MERRELL DOW PHARMA (US) | 1995-03-01 | — | — | EP | disclosed |