Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9030998 | 0.92 | HTR1D (0.50) | HTR1DHTR1BHTR1APARP1DRD2 | |
| SCHEMBL9032203 | 0.91 | HTR1D (0.49) | HTR1DHTR1BHTR1APARP1DRD2 | |
| SCHEMBL9031902 | 0.84 | HTR1D (0.50) | HTR1DHTR1BHTR1APARP1GAA | |
| SCHEMBL9031016 | 0.81 | DRD2 (0.47) | HTR1DHTR1BHTR1APARP1DRD2 | |
| SCHEMBL6042752 | 0.81 | DRD2 (0.63) | HTR1AGAAHTTDRD2KDM4E | |
| SCHEMBL11828531 | 0.80 | HTR1A (0.47) | HTR1APARP1DRD2KDM4ELMNA | |
| SCHEMBL9676905 | 0.80 | HTR1D (0.44) | HTR1DHTR1BHTR1AGAAHTT | |
| Hydrochloric Acid SCHEMBL9324885 | 0.80 | HTR1D (0.44) | HTR1DHTR1BHTR1AGAAHTT | |
| Hydrochloric Acid SCHEMBL6374514 | 0.79 | SIGMAR1 (0.58) | HTR1ADRD2 | |
| SCHEMBL9175703 | 0.79 | DRD2 (0.46) | HTR1DHTR1BHTR1APARP1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0735024-A1 | Antidepressant N-(Heteroarylaminoalkyl)-4-napthyl substituted piperidines and tetrahydroperidines | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-02 | — | — | EP | disclosed |
| US-5472966-A | Antiserotonin agents; side effect reduction | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-12-05 | — | — | US | disclosed |
| US-5292761-A | Piperidine, tetrahydropyridine and pyrrolidine compounds | ADIR ET COMPAGNIE (FR) | 1994-03-08 | — | — | US | disclosed |
| US-5278185-A | Piperidine, Tetrahydropyridine and pyrrolidine compounds | ADIR ET COMPAGNIE (FR) | 1994-01-11 | — | — | US | disclosed |
| US-5260317-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-11-09 | — | — | US | disclosed |
| US-5250544-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-10-05 | — | — | US | disclosed |
| US-5242933-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-09-07 | — | — | US | disclosed |
| US-5240942-A | Hypotensive agents; 5-hydroxytryptamine antagonist | ADIR ET COMPAGNIE (FR) | 1993-08-31 | — | — | US | disclosed |
| EP-0466585-A1 | Novel piperidin, tetrahydropyridine and pyrrolidine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-01-15 | — | — | EP | disclosed |