Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 7/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 7/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8149708 | 0.77 | ALDH1A1 (0.46) | CHRM2CHRM5CHRM1LMNAALDH1A1 | |
| SCHEMBL11210727 | 0.77 | KMT2A (0.55) | CHRM2CHRM5CHRM1ALDH1A1KMT2A | |
| SCHEMBL9029818 | 0.76 | CHRM2 (1.00) | CHRM2CHRM5CHRM1LMNACHRM4 | |
| SCHEMBL8697896 | 0.76 | KMT2A (0.53) | CHRM2CHRM5CHRM1ALDH1A1KMT2A | |
| SCHEMBL1956056 | 0.74 | — | — | |
| SCHEMBL5494269 | 0.71 | — | — | |
| SCHEMBL16486488 | 0.71 | — | — | |
| SCHEMBL9030400 | 0.70 | LMNA (0.47) | LMNA | |
| SCHEMBL892987 | 0.68 | LMNA (1.00) | CHRM2CHRM5CHRM1LMNACHRM4 | |
| SCHEMBL4779659 | 0.67 | ALDH1A1 (0.72) | LMNAALDH1A1KMT2APOLBP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426714-B1 | ACETYLENIC IMIDAZOLES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | UPJOHN CO (US) | 1996-04-03 | — | — | EP | claimed |
| EP-0426714-A1 | ACETYLENIC IMIDAZOLES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY. | UPJOHN CO (US) | 1991-05-15 | — | — | EP | claimed |
| WO-1990001026-A1 | ACETYLENIC IMIDAZOLES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1990-02-08 | — | — | WO | claimed |
| EP-0426714-B1 | ACETYLENIC IMIDAZOLES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | UPJOHN CO (US) | 1996-04-03 | — | — | EP | disclosed |
| US-5100909-A | Cholinergic antagonists, analgesics, treatment of Alzheimer*s disease | THE UPJOHN COMPANY (US) | 1992-03-31 | — | — | US | disclosed |
| EP-0426714-A1 | ACETYLENIC IMIDAZOLES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY. | UPJOHN CO (US) | 1991-05-15 | — | — | EP | disclosed |
| WO-1990001026-A1 | ACETYLENIC IMIDAZOLES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1990-02-08 | — | — | WO | disclosed |