Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.69 |
| ▸ | CCR3 | P51677 | 1/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6403439 | 0.89 | ACHE (0.60) | ACHECCR3SLC6A3SIGMAR1HTR2A | |
| SCHEMBL4255182 | 0.83 | ACHE (0.71) | ACHECCR3SLC6A3SIGMAR1HTR2A | |
| SCHEMBL6056974 | 0.82 | SLC6A3 (0.83) | ACHECCR3SLC6A3SIGMAR1KCNH2 | |
| SCHEMBL14407778 | 0.82 | SLC6A3 (0.83) | ACHECCR3SLC6A3SIGMAR1KCNH2 | |
| SCHEMBL7264546 | 0.82 | SLC6A3 (0.83) | ACHECCR3SLC6A3SIGMAR1KCNH2 | |
| SCHEMBL13150782 | 0.82 | SLC6A3 (0.83) | ACHECCR3SLC6A3SIGMAR1KCNH2 | |
| SCHEMBL4255190 | 0.81 | ACHE (0.69) | ACHECCR3SLC6A3SIGMAR1HTR2A | |
| SCHEMBL152736 | 0.81 | ACHE (1.00) | ACHECCR3SLC6A3SIGMAR1HTR2A | |
| SCHEMBL4252568 | 0.81 | ACHE (0.69) | ACHECCR3SLC6A3SIGMAR1HTR2A | |
| SCHEMBL1803484 | 0.81 | ACHE (0.69) | ACHECCR3SLC6A3SIGMAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1124026-A | Thioindole pyperidinyl derivatives used as antalgics | UNION PHARMA SCIENT APPL (FR) | 1996-06-05 | — | — | CN | disclosed |
| EP-0699195-A1 | THIOINDOLE PYPERIDINYL DERIVATIVES USED AS ANTALGICS | LABORATOIRES UPSA (FR) | 1996-03-06 | — | — | EP | disclosed |
| US-5418242-A | Piperidinylthioindole derivatives, their methods of preparation and pharmaceutical compositions in which they are present, useful especially as analgesics | LABORATOIRES UPSA (FR) | 1995-05-23 | — | — | US | disclosed |
| WO-1994026736-A1 | THIOINDOLE PYPERIDINYL DERIVATIVES USED AS ANTALGICS | LABORATOIRES UPSA (FR) | 1994-11-24 | — | — | WO | disclosed |
| US-5317025-A | Piperidinylthioindole derivatives, their methods of preparation and pharmaceutical compositions in which they are present, useful especially as analgesics | LABORATOIRES USPA (FR) | 1994-05-31 | — | — | US | disclosed |