Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.68 |
| ▸ | GAA | P10253 | 9/20 | 0.68 |
| ▸ | MEN1 | O00255 | 8/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | HPGD | P15428 | 7/20 | 0.68 |
| ▸ | USP2 | O75604 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 5/20 | 0.68 |
| ▸ | GLA | P06280 | 5/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.68 |
| ▸ | CASP1 | P29466 | 4/20 | 0.68 |
| ▸ | CASP7 | P55210 | 4/20 | 0.68 |
| ▸ | ATM | Q13315 | 2/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.65 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.65 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24623305 | 0.91 | ALDH1A1 (0.64) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL1213320 | 0.89 | KMT2A (0.63) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL14303297 | 0.89 | ALDH1A1 (0.63) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL1212238 | 0.89 | ALDH1A1 (0.63) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL1212937 | 0.89 | ALDH1A1 (0.67) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL12892379 | 0.89 | ALDH1A1 (0.63) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL3202594 | 0.86 | KMT2A (0.61) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL14303302 | 0.86 | KMT2A (0.67) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL14303304 | 0.86 | KMT2A (0.60) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| Hydrochloric Acid SCHEMBL31718750 | 0.85 | KMT2A (0.60) | ALDH1A1KDM4EKMT2AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160334393-A1 | Use of Novel Coumarins as Glutathione and Thiol Labels | Life Technologies Corporation | 2016-11-17 | — | — | US | disclosed |
| US-20150219634-A1 | Use of Novel Coumarins as Glutathione and Thiol Labels | LIFE TECHNOLOGIES CORP (US) | 2015-08-06 | — | — | US | disclosed |
| US-8981100-B2 | Use of novel coumarins as glutathione and thiol labels | Life Technologies Corporation (US) | 2015-03-17 | — | — | US | disclosed |
| WO-2012041851-A1 | SECURITY ELEMENT | BASF SE (DE) | 2012-04-05 | — | — | WO | disclosed |
| US-20110045503-A1 | The Use of Novel Coumarins as Glutathione and Thiol Labels | Life Technologies Corporation (US) | 2011-02-24 | — | — | US | disclosed |
| US-20100048604-A1 | Ligands for Aldoketoreductases | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2010-02-25 | — | — | US | disclosed |
| US-20100048604-A1 | Ligands for Aldoketoreductases | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150219634-A1 | Use of Novel Coumarins as Glutathione and Thiol Labels | GSTP1, GSTK1, GSTA1 | ALDH1A1 341/4885KDM4E 4664/4885KMT2A 4686/4885 |
| US-20100048604-A1 | Ligands for Aldoketoreductases | AKR1C2, AKR1C1, AKR1B1 | ALDH1A1 18/4885KDM4E 2592/4885KMT2A 3808/4885 |
| US-20160334393-A1 | Use of Novel Coumarins as Glutathione and Thiol Labels | GSTP1, GSTK1, GSTA1 | ALDH1A1 341/4885KDM4E 4664/4885KMT2A 4686/4885 |
| US-20110045503-A1 | The Use of Novel Coumarins as Glutathione and Thiol Labels | GSTP1, GSTK1, GSTA1 | ALDH1A1 365/4885KDM4E 4635/4885KMT2A 4601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.