SCHEMBL1212937

SCHEMBL1212937

O=c1cc(CBr)c2cc3c4c(c2o1)CCCN4CCC3

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 12/20 0.67
▸ KMT2A Q03164 11/20 0.67
▸ KDM4E B2RXH2 10/20 0.67
▸ MEN1 O00255 9/20 0.67
▸ USP2 O75604 6/20 0.67
▸ MAPT P10636 6/20 0.67
▸ GAA P10253 6/20 0.67
▸ LMNA P02545 5/20 0.67
▸ HSD17B10 Q99714 5/20 0.67
▸ HPGD P15428 4/20 0.67
▸ CASP1 P29466 4/20 0.67
▸ CASP7 P55210 4/20 0.67
▸ GLA P06280 2/20 0.67
▸ ATM Q13315 2/20 0.67
▸ L3MBTL1 Q9Y468 2/20 0.67
▸ TDP1 Q9NUW8 3/20 0.63
▸ HTT P42858 2/20 0.63
▸ KEAP1 Q14145 1/20 0.63
▸ NFE2L2 Q16236 1/20 0.63
▸ GPR35 Q9HC97 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL903151 0.89 ALDH1A1 (0.68) ALDH1A1KMT2AKDM4EMEN1USP2
SCHEMBL1213320 0.88 KMT2A (0.63) ALDH1A1KMT2AKDM4EMEN1USP2
SCHEMBL12892379 0.88 ALDH1A1 (0.63) ALDH1A1KMT2AKDM4EMEN1USP2
SCHEMBL1212238 0.88 ALDH1A1 (0.63) ALDH1A1KMT2AKDM4EMEN1USP2
SCHEMBL14303297 0.88 ALDH1A1 (0.63) ALDH1A1KMT2AKDM4EMEN1USP2
SCHEMBL24623305 0.85 ALDH1A1 (0.64) ALDH1A1KMT2AKDM4EMEN1USP2
SCHEMBL3202594 0.85 KMT2A (0.61) ALDH1A1KMT2AKDM4EMEN1USP2
SCHEMBL14303302 0.85 KMT2A (0.67) ALDH1A1KMT2AKDM4EMEN1USP2
Hydrochloric Acid SCHEMBL31718750 0.84 KMT2A (0.60) ALDH1A1KMT2AKDM4EMEN1USP2
SCHEMBL13486811 0.82 KMT2A (0.57) ALDH1A1KMT2AKDM4EMEN1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160334393-A1 Use of Novel Coumarins as Glutathione and Thiol Labels Life Technologies Corporation 2016-11-17 — — US claimed
US-8981100-B2 Use of novel coumarins as glutathione and thiol labels Life Technologies Corporation (US) 2015-03-17 — — US claimed
US-20110045503-A1 The Use of Novel Coumarins as Glutathione and Thiol Labels Life Technologies Corporation (US) 2011-02-24 — — US claimed
US-12637489-B2 Silicon containing modified nucleotide analogs Singular Genomics Systems, Inc. (US) 2026-05-26 — — US disclosed
US-12630808-B2 Modified archaeal family b polymerases Singular Genomics Systems, Inc. (US) 2026-05-19 — — US disclosed
US-20260125660-A1 MODIFIED ARCHAEAL FAMILY B POLYMERASES SINGULAR GENOMICS SYSTEMS INC (US) 2026-05-07 — — US disclosed
US-20260110028-A1 NUCLEOTIDE ANALOGS AND USES THEREOF SINGULAR GENOMICS SYSTEMS INC (US) 2026-04-23 — — US disclosed
US-12595508-B2 Nucleotide cleavable linkers and uses thereof Singular Genomics Systems, Inc. (US) 2026-04-07 — — US disclosed
US-20260085299-A1 ENGINEERED PYROCOCCUS ENZYMES AND USES THEREOF SINGULAR GENOMICS SYSTEMS INC (US) 2026-03-26 — — US disclosed
EP-4713368-A1 ANTI-CD28 ANTIBODIES AND METHODS RELATED THERETO Adimab, LLC (US) 2026-03-25 — — EP disclosed
US-12577271-B2 Modified nucleotides and uses thereof Singular Genomics Systems, Inc. (US) 2026-03-17 — — US disclosed
US-8981100-B2 Use of novel coumarins as glutathione and thiol labels Life Technologies Corporation (US) 2015-03-17 — — US disclosed
US-8981100-B2 Use of novel coumarins as glutathione and thiol labels Life Technologies Corporation (US) 2015-03-17 — — US disclosed
US-20150064703-A1 RAPID ANTIBIOTIC SUSCEPTIBILITY TESTING PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2015-03-05 — — US disclosed
EP-2820147-A1 RAPID ANTIBIOTIC SUSCEPTIBILITY TESTING President and Fellows of Harvard College (US) 2015-01-07 — — EP disclosed
WO-2013130875-A1 RAPID ANTIBIOTIC SUSCEPTIBILITY TESTING PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2013-09-06 — — WO disclosed
US-20110045503-A1 The Use of Novel Coumarins as Glutathione and Thiol Labels Life Technologies Corporation (US) 2011-02-24 — — US disclosed
US-20110045503-A1 The Use of Novel Coumarins as Glutathione and Thiol Labels Life Technologies Corporation (US) 2011-02-24 — — US disclosed
US-20110045503-A1 The Use of Novel Coumarins as Glutathione and Thiol Labels Life Technologies Corporation (US) 2011-02-24 — — US disclosed
WO-2009018112-A2 THE USE OF NOVEL COUMARINS AS GLUTATHIONE AND THIOL LABELS INVITROGEN CORPORATION (US) 2009-02-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12630808-B2 Modified archaeal family b polymerases SSU72, POLB, POLQ ALDH1A1 2884/4885KMT2A 308/4885KDM4E 1080/4885
US-12595508-B2 Nucleotide cleavable linkers and uses thereof NSUN2, CCRL2, NOP2 ALDH1A1 3274/4885KMT2A 2804/4885KDM4E 4144/4885
US-12577271-B2 Modified nucleotides and uses thereof NUDT1, NSUN2, CCRL2 ALDH1A1 2320/4885KMT2A 2809/4885KDM4E 4569/4885
US-12637489-B2 Silicon containing modified nucleotide analogs NSUN2, POLR2H, POLH ALDH1A1 3879/4885KMT2A 2375/4885KDM4E 4429/4885
US-20260110028-A1 NUCLEOTIDE ANALOGS AND USES THEREOF POLL, POLB, POLN ALDH1A1 2325/4885KMT2A 1209/4885KDM4E 2493/4885
US-20260085299-A1 ENGINEERED PYROCOCCUS ENZYMES AND USES THEREOF POLB, POLM, POLRMT ALDH1A1 4563/4885KMT2A 1696/4885KDM4E 1438/4885
US-20160334393-A1 Use of Novel Coumarins as Glutathione and Thiol Labels GSTP1, GSTK1, GSTA1 ALDH1A1 341/4885KMT2A 4686/4885KDM4E 4664/4885
US-20110045503-A1 The Use of Novel Coumarins as Glutathione and Thiol Labels GSTP1, GSTK1, GSTA1 ALDH1A1 365/4885KMT2A 4601/4885KDM4E 4635/4885
US-20260125660-A1 MODIFIED ARCHAEAL FAMILY B POLYMERASES DNMT3A, POLB, POLM ALDH1A1 3860/4885KMT2A 755/4885KDM4E 995/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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