Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032003 | 0.84 | DHFR (0.42) | PDE4ANPC1MAPTALDH1A1S1PR1 | |
| SCHEMBL9026325 | 0.81 | CYP11B2 (0.46) | PDE4ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9025501 | 0.78 | HPGD (0.50) | NPC1MAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9026850 | 0.78 | KDM4E (0.50) | NPC1MAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL9025514 | 0.78 | PDE4A (0.39) | PDE4ANPC1MAPTALDH1A1S1PR1 | |
| SCHEMBL9026001 | 0.77 | KMT2A (0.42) | NPC1ALDH1A1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL9025085 | 0.77 | RAB9A (0.43) | NPC1MAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9025551 | 0.77 | KDM4E (0.43) | NPC1MAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9216010 | 0.77 | RAB9A (0.42) | NPC1MAPTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9024885 | 0.77 | KDM4E (0.43) | NPC1ALDH1A1SMN1; SMN2L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |