Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXER1 | Q8TDS5 | 2/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | KRAS | P01116 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659180 | 0.87 | OXER1 (0.63) | OXER1ROCK2PIM1PIM3HTR2A | |
| SCHEMBL8132976 | 0.82 | OXER1 (0.57) | OXER1ROCK2PIM1PIM3HTR2A | |
| SCHEMBL29949827 | 0.79 | ROCK2 (0.52) | ROCK2PIM1PIM3PARP1KDM4E | |
| SCHEMBL5785852 | 0.79 | HTR2A (0.44) | OXER1PIM1HTR2AHTR2CPARP1 | |
| SCHEMBL30740677 | 0.79 | TFPI2 (0.50) | OXER1HTR2AHTR2CPARP1KDM4E | |
| SCHEMBL28655804 | 0.78 | OXER1 (0.54) | OXER1ROCK2PIM1PIM3HTR2A | |
| SCHEMBL20905233 | 0.78 | OXER1 (0.54) | OXER1ROCK2PIM1PIM3HTR2A | |
| SCHEMBL31517107 | 0.78 | OXER1 (0.54) | OXER1ROCK2PIM1PIM3HTR2A | |
| SCHEMBL31435522 | 0.77 | RAB9A (0.66) | OXER1ROCK2PIM1PIM3KDM4E | |
| SCHEMBL8132979 | 0.76 | OXER1 (0.55) | OXER1ROCK2PIM1PIM3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017023894-A1 | MTHFD2 INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-02-09 | — | — | WO | disclosed |
| EP-0686148-A4 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO INC (US) | 1996-02-07 | — | — | EP | disclosed |
| EP-0686148-A1 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO. INC. (US) | 1995-12-13 | — | — | EP | disclosed |