Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8708616 | 0.98 | MAOA (0.40) | JAK2JAK1JAK3MAOAALDH1A1 | |
| SCHEMBL8417992 | 0.83 | JAK2 (0.36) | JAK2JAK1JAK3MAOAALDH1A1 | |
| SCHEMBL9033513 | 0.81 | KCNA3 (0.41) | JAK2JAK1JAK3ALDH1A1TRPM8 | |
| Hydrochloric Acid SCHEMBL8704982 | 0.80 | KCNA3 (0.40) | JAK2JAK1JAK3MAOAALDH1A1 | |
| SCHEMBL8705292 | 0.79 | TSHR (0.35) | JAK2JAK1JAK3MAOAALDH1A1 | |
| SCHEMBL9035643 | 0.78 | ALDH1A1 (0.33) | JAK2JAK1JAK3MAOAALDH1A1 | |
| SCHEMBL9033574 | 0.76 | NPC1 (0.42) | ALDH1A1TRPM8TSHRMEN1KMT2A | |
| SCHEMBL9033105 | 0.73 | TRPM8 (0.31) | ALDH1A1TRPM8MEN1KMT2ACRHR1 | |
| SCHEMBL9034539 | 0.72 | TRPM8 (0.33) | TRPM8SMN1; SMN2MEN1KMT2ACRHR1 | |
| SCHEMBL8989389 | 0.71 | JAK2 (0.35) | JAK2JAK1JAK3MAOALRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0719256-A1 | SUBSTITUTED PYRIDINES, PROCESS FOR PRODUCING THEM AND THEIR USE AS PESTICIDES AND FUNGICIDES | Hoechst Schering AgrEvo GmbH (DE) | 1996-07-03 | — | — | EP | disclosed |
| WO-1995007891-A1 | SUBSTITUTED PYRIDINES, PROCESS FOR PRODUCING THEM AND THEIR USE AS PESTICIDES AND FUNGICIDES | HOECHST SCHERING AGREVO GMBH (DE) | 1995-03-23 | — | — | WO | disclosed |