SCHEMBL9034233

SCHEMBL9034233

Cc1sc(-c2ccncc2)cc1Br

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.45
CDC7 O00311 10/20 0.43
DBF4 Q9UBU7 10/20 0.43
ROCK1 Q13464 6/20 0.39
CCNE1 P24864 4/20 0.39
CDK2 P24941 4/20 0.39
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
PRKCI P41743 1/20 0.39
MAPT P10636 2/20 0.37
LMNA P02545 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17376763 0.80 CYP2A6 (0.47) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL6812091 0.80 MAPT (0.40) MAPTLMNAKDM4ECYP1A2CYP3A4
SCHEMBL28848007 0.80 ESR1 (0.43) MAPTLMNAKDM4ECYP1A2CYP2C9
SCHEMBL27811389 0.80 NPC1 (0.42) MAPTKDM4ECYP1A2CYP2C9CYP2C19
SCHEMBL27797494 0.77 IKBKB (0.40) HDAC6MAPTTSHRKDM4ECYP1A2
SCHEMBL27499183 0.77 CDC7 (0.43) GSK3BCDC7DBF4ROCK1CCNE1
SCHEMBL19887438 0.76 PIK3CA (0.38) PRKCILMNANPC1RAB9A
SCHEMBL4627777 0.76 HCAR3 (0.32)
SCHEMBL12876559 0.76 ALDH1A1 (0.42) HDAC4HDAC1HDAC6LMNATSHR
SCHEMBL566698 0.74 APP (0.55) HDAC6MAPTTSHRKDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019000024-A1 HIGHLY EMISSIVE PYRIDINIUM ENOLATES THE UNIVERSITY OF MELBOURNE (AU) 2019-01-03 WO disclosed
WO-2015197187-A1 PYRAZOLYL-BASED CARBOXAMIDES V Grünenthal GmbH (DE) 2015-12-30 WO disclosed
EP-0717740-A1 PHOTOCHROMIC COMPOUNDS, METHODS AND INTERMEDIATES FOR PRODUCING THEM AND THEIR USE Ciba SC Holding AG (CH) 1996-06-26 EP disclosed
WO-1995007275-A1 PHOTOCHROMIC COMPOUNDS, METHODS AND INTERMEDIATES FOR PRODUCING THEM AND THEIR USE CIBA-GEIGY AG (CH) 1995-03-16 WO disclosed