Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | HPN | P05981 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 2/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903524 | 0.90 | KDM4E (0.50) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL12826014 | 0.81 | LPL (0.36) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL903530 | 0.80 | KDM4E (0.60) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL10793244 | 0.76 | KDM4E (0.72) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL6118322 | 0.73 | RAB9A (0.64) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL10799107 | 0.73 | KDM4E (0.73) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL1460260 | 0.73 | IDO1 (0.45) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL6118259 | 0.73 | KDM4E (0.72) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL15060416 | 0.73 | KDM4E (0.68) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL4264688 | 0.71 | KDM4E (0.81) | KDM4EMEN1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041014-A1 | TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012040923-A1 | TETRACYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |