Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | AXL | P30530 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.54 |
| ▸ | HPN | P05981 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | ITK | Q08881 | 2/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903538 | 0.90 | FLT3 (0.58) | KDM4EMEN1KMT2ANPC1MAPT | |
| SCHEMBL11650959 | 0.88 | RAB9A (0.63) | KDM4EMEN1KMT2ANPC1MAPT | |
| SCHEMBL10793244 | 0.83 | KDM4E (0.72) | KDM4EMEN1KMT2ANPC1MAPT | |
| SCHEMBL6245990 | 0.80 | AXL (0.51) | KDM4EMEN1KMT2ANPC1MAPT | |
| SCHEMBL903541 | 0.80 | KDM4E (0.52) | KDM4EMEN1KMT2ANPC1MAPT | |
| SCHEMBL4264688 | 0.78 | KDM4E (0.81) | KDM4EMEN1KMT2ANPC1MAPT | |
| SCHEMBL19889776 | 0.78 | CDK5 (0.51) | KDM4EMEN1KMT2AMAPTCA2 | |
| SCHEMBL9469072 | 0.77 | KDM4E (0.64) | KDM4EMEN1KMT2ANPC1MAPT | |
| SCHEMBL6118322 | 0.77 | RAB9A (0.64) | KDM4EMEN1KMT2ANPC1MAPT | |
| SCHEMBL31185862 | 0.77 | KDM4E (0.56) | KDM4EMEN1KMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041014-A1 | TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |
| WO-2012040923-A1 | TETRACYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |