Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9034427 | 0.89 | OPRM1 (0.57) | MAPTHTR1ASLC6A4HTR7DRD2 | |
| SCHEMBL9033683 | 0.89 | SLC6A4 (0.64) | HTR1ASLC6A4HTR7DRD2HTR6 | |
| SCHEMBL9033765 | 0.88 | HTR1D (0.49) | MAPTHTR1ASLC6A4HTR7DRD2 | |
| SCHEMBL9034645 | 0.87 | RAD52 (0.51) | MAPTHTR1ASLC6A4HTR7DRD2 | |
| SCHEMBL9032917 | 0.86 | SLC6A4 (0.65) | HTR1ASLC6A4HTR7DRD2HTR6 | |
| SCHEMBL9051682 | 0.86 | KCNH2 (0.52) | HTR1ASLC6A4HTR7DRD2HTR6 | |
| SCHEMBL9034449 | 0.85 | SLC6A4 (0.49) | HTR1ASLC6A4DRD2MEN1KMT2A | |
| SCHEMBL5705223 | 0.85 | CYP1A2 (0.56) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL9033713 | 0.84 | SLC6A4 (0.51) | HTR1ASLC6A4HTR7DRD2HTR6 | |
| SCHEMBL9035794 | 0.83 | HTR1D (0.49) | MAPTHTR1ASLC6A4DRD2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |