Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95381 | 0.81 | TSHR (0.44) | MAOBRAB9ASMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL7086574 | 0.80 | LMNA (0.48) | SMN1; SMN2GAAL3MBTL1KMT2AKDM4E | |
| SCHEMBL27802210 | 0.78 | MAOB (0.46) | MAOBRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL1907545 | 0.78 | MAOB (0.43) | MAOBRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL6796911 | 0.78 | MAOB (0.44) | MAOBRAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2451731 | 0.78 | MAOB (0.43) | MAOBRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL5790467 | 0.78 | TP53 (0.40) | NPC1SMN1; SMN2L3MBTL1KMT2AKDM4E | |
| SCHEMBL3973667 | 0.78 | IDO1 (0.48) | GAASMPD1KMT2AHPGD | |
| SCHEMBL28273577 | 0.77 | KDM4E (0.44) | KDM4ELOXL2ALDH1A1 | |
| SCHEMBL13722512 | 0.77 | MAOB (0.44) | MAOBRAB9ASMPD1CYP2A6LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365328-B1 | Pyridine derivatives | ZENECA LTD (GB) | 1996-04-03 | — | — | EP | disclosed |
| US-5053415-A | Antiischemic, antiinflammatory, antiarthritic agents, cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-10-01 | — | — | US | disclosed |
| EP-0365328-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1990-04-25 | — | — | EP | disclosed |