Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 7/20 | 0.54 |
| ▸ | MAOB | P27338 | 7/20 | 0.54 |
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2207553 | 0.86 | NPC1 (0.64) | RAB9ANPC1TDP1ALDH1A1MAPT | |
| SCHEMBL24489133 | 0.86 | ALDH1A1 (0.65) | RAB9ANPC1TDP1ALDH1A1MAPT | |
| SCHEMBL9267565 | 0.80 | NPC1 (1.00) | RAB9ANPC1TDP1MAOAMAOB | |
| SCHEMBL28586185 | 0.80 | NPC1 (0.78) | RAB9ANPC1TDP1MAOAMAOB | |
| SCHEMBL29399968 | 0.79 | NPC1 (0.65) | RAB9ANPC1TDP1ALDH1A1POLB | |
| SCHEMBL23188 | 0.79 | NPC1 (0.65) | RAB9ANPC1TDP1ALDH1A1POLB | |
| SCHEMBL7684603 | 0.79 | NPC1 (0.65) | RAB9ANPC1TDP1ALDH1A1POLB | |
| SCHEMBL29998099 | 0.77 | NPC1 (0.63) | RAB9ANPC1TDP1ALDH1A1POLB | |
| Ethane SCHEMBL1494210 | 0.77 | NPC1 (0.63) | RAB9ANPC1TDP1ALDH1A1POLB | |
| SCHEMBL2548051 | 0.77 | ALDH1A1 (0.66) | RAB9ANPC1ALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1034120-C | Pyridine derivatives | ZENECA LTD (GB) | 1997-02-26 | — | — | CN | disclosed |
| EP-0365328-B1 | Pyridine derivatives | ZENECA LTD (GB) | 1996-04-03 | — | — | EP | disclosed |
| US-5053415-A | Antiischemic, antiinflammatory, antiarthritic agents, cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-10-01 | — | — | US | disclosed |
| CN-1041942-A | Pyridine derivate | ICI PLC (GB) | 1990-05-09 | — | — | CN | disclosed |
| EP-0365328-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1990-04-25 | — | — | EP | disclosed |