Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9037928 | 0.89 | KDM1A (0.46) | SIGMAR1KDM1A | |
| SCHEMBL9040970 | 0.88 | SIGMAR1 (0.46) | SIGMAR1KDM1A | |
| SCHEMBL9040756 | 0.79 | DRD1 (0.48) | — | |
| SCHEMBL9040998 | 0.78 | SIGMAR1 (0.47) | MAOBMAOASIGMAR1 | |
| SCHEMBL9038214 | 0.78 | DRD1 (0.47) | — | |
| SCHEMBL9041165 | 0.77 | DRD1 (0.50) | SIGMAR1 | |
| SCHEMBL9040302 | 0.76 | DRD1 (0.49) | SIGMAR1 | |
| SCHEMBL23385699 | 0.73 | SIGMAR1 (0.44) | MAPK1SMN1; SMN2MAOBSIGMAR1ALDH1A1 | |
| SCHEMBL18559550 | 0.72 | HTR2A (0.39) | MAOBMAOA | |
| SCHEMBL21788652 | 0.72 | SIGMAR1 (0.54) | SIGMAR1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441598-B1 | Spiroisoindole compounds | ZENECA INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5098925-A | Neurological disorders in mammals | ICI AMERICAS INC. (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0441598-A2 | Spiroisoindole compounds | ZENECA INC. (US) | 1991-08-14 | — | — | EP | disclosed |