Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 6/20 | 0.49 |
| ▸ | DRD5 | P21918 | 5/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | DRD4 | P21917 | 4/20 | 0.49 |
| ▸ | DRD3 | P35462 | 4/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9041165 | 0.96 | DRD1 (0.50) | DRD1DRD5DRD2DRD4DRD3 | |
| SCHEMBL9040970 | 0.87 | SIGMAR1 (0.46) | SIGMAR1AKR1B1 | |
| SCHEMBL9040626 | 0.85 | DRD1 (0.47) | DRD1DRD5DRD2DRD4DRD3 | |
| SCHEMBL9037928 | 0.82 | KDM1A (0.46) | SIGMAR1AKR1B1 | |
| SCHEMBL9038214 | 0.82 | DRD1 (0.47) | DRD1DRD5DRD2DRD4DRD3 | |
| SCHEMBL9040756 | 0.78 | DRD1 (0.48) | DRD1DRD5DRD2DRD4DRD3 | |
| SCHEMBL9038313 | 0.76 | MAPK1 (0.42) | SIGMAR1 | |
| SCHEMBL9039535 | 0.71 | AKR1B1 (0.46) | SIGMAR1AKR1B1 | |
| SCHEMBL9040061 | 0.69 | SIGMAR1 (0.50) | SIGMAR1 | |
| SCHEMBL9039447 | 0.69 | SIGMAR1 (0.46) | DRD1DRD5DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441598-B1 | Spiroisoindole compounds | ZENECA INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5098925-A | Neurological disorders in mammals | ICI AMERICAS INC. (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0441598-A2 | Spiroisoindole compounds | ZENECA INC. (US) | 1991-08-14 | — | — | EP | disclosed |