Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9037928 | 0.95 | KDM1A (0.46) | SIGMAR1KDM1AAKR1B1 | |
| SCHEMBL9038214 | 0.89 | DRD1 (0.47) | — | |
| SCHEMBL9038313 | 0.88 | MAPK1 (0.42) | SIGMAR1KDM1A | |
| SCHEMBL9040302 | 0.87 | DRD1 (0.49) | SIGMAR1AKR1B1 | |
| SCHEMBL9040756 | 0.84 | DRD1 (0.48) | — | |
| SCHEMBL9041165 | 0.82 | DRD1 (0.50) | SIGMAR1AKR1B1 | |
| SCHEMBL9040061 | 0.80 | SIGMAR1 (0.50) | SIGMAR1 | |
| SCHEMBL9037683 | 0.75 | SIGMAR1 (0.49) | SIGMAR1 | |
| SCHEMBL7213608 | 0.71 | KDM1A (0.53) | SIGMAR1KDM1A | |
| SCHEMBL12084851 | 0.70 | SIGMAR1 (0.57) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441598-B1 | Spiroisoindole compounds | ZENECA INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5098925-A | Neurological disorders in mammals | ICI AMERICAS INC. (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0441598-A2 | Spiroisoindole compounds | ZENECA INC. (US) | 1991-08-14 | — | — | EP | disclosed |