Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038809 | 0.88 | SIRT1 (0.34) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL9040240 | 0.74 | KDM1A (0.37) | ADRA1AKDM1AMAOBMAOA | |
| SCHEMBL9039255 | 0.74 | KDM1A (0.37) | ADRA1AKDM1AMAOBMAOA | |
| SCHEMBL10380124 | 0.70 | L3MBTL1 (0.35) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL9039581 | 0.70 | PARP1 (0.33) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL612073 | 0.69 | PDE4A (0.41) | KDM4EALDH1A1MAPTSIRT1LMNA | |
| SCHEMBL10380075 | 0.67 | ADRA1A (0.41) | KDM4EHPGDSMN1; SMN2ADRA1ASIRT1 | |
| SCHEMBL7304489 | 0.67 | KDM1A (0.39) | ALDH1A1ADRA1AKDM1AMAOBMAOA | |
| SCHEMBL9040854 | 0.66 | KDM1A (0.35) | KMT2AADRA1AKDM1AMAOBMAOA | |
| SCHEMBL9042337 | 0.66 | KDM1A (0.35) | KMT2AADRA1AKDM1AMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474767-B1 | DOPAMINE AGONISTS | ABBOTT LAB (US) | 1996-02-21 | — | — | EP | disclosed |
| WO-1990015056-A1 | DOPAMINE AGONISTS | ABBOTT LABORATORIES (US) | 1990-12-13 | — | — | WO | disclosed |