Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038809 | 0.72 | SIRT1 (0.34) | PDE4APDE4BPDE4CPDE4DKDM1A | |
| SCHEMBL9038554 | 0.70 | KDM4E (0.35) | PDE4APDE4BPDE4CPDE4DKDM1A | |
| SCHEMBL10380124 | 0.64 | L3MBTL1 (0.35) | HPGDALDH1A1HSD17B10 | |
| SCHEMBL10835939 | 0.60 | PARP1 (0.45) | PARP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL559163 | 0.60 | PARP1 (0.47) | PARP1KDM1AMAOAMAOBKDM4E | |
| SCHEMBL612710 | 0.59 | PARP1 (0.46) | PARP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL613222 | 0.59 | PARP1 (0.46) | PARP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL612709 | 0.59 | PARP1 (0.46) | PARP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL613221 | 0.59 | PARP1 (0.46) | PARP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28716613 | 0.58 | ALDH1A1 (0.51) | MAOBKDM4EHPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474767-B1 | DOPAMINE AGONISTS | ABBOTT LAB (US) | 1996-02-21 | — | — | EP | disclosed |
| WO-1990015056-A1 | DOPAMINE AGONISTS | ABBOTT LABORATORIES (US) | 1990-12-13 | — | — | WO | disclosed |