Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5368228 | 0.79 | MAPT (0.48) | IDO1MAPTMEN1KMT2AHTT | |
| SCHEMBL14400038 | 0.79 | IDO1 (0.58) | IDO1KDM4EALDH1A1TSHRMAPK1 | |
| SCHEMBL9263103 | 0.79 | ALDH1A1 (0.41) | IDO1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL8252117 | 0.76 | MGAM (0.47) | MAPTMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL29573133 | 0.73 | GPR35 (0.53) | GPR35IDO1MAPTMEN1KMT2A | |
| SCHEMBL11518803 | 0.73 | GPR35 (0.53) | GPR35IDO1MAPTMEN1KMT2A | |
| SCHEMBL1857660 | 0.73 | IDO1 (0.53) | IDO1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL25377636 | 0.72 | S100A4 (0.42) | IDO1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL30510054 | 0.72 | S100A4 (0.42) | IDO1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL31402956 | 0.71 | CHEK1 (0.34) | GPR35MAPTKDM4ECHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518530-B1 | Improvements in or relating to excitatory amino acid receptor antagonists | LILLY CO ELI (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5196421-A | Treatment of neurological disorders | ELI LILLY AND COMPANY (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0518530-A2 | Improvements in or relating to excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1992-12-16 | — | — | EP | disclosed |
| US-5153196-A | Administering for reduction of neurotransmission in nervous system disorders | ELI LILLY AND COMPANY (US) | 1992-10-06 | — | — | US | disclosed |