Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | TYMS | P04818 | 3/20 | 0.40 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.40 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.40 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9041283 | 0.91 | GART (0.45) | GARTDHFRTYMSFOLR2FOLR1 | |
| SCHEMBL9042993 | 0.87 | GART (0.48) | GARTDHFRTYMSFOLR2FOLR1 | |
| SCHEMBL9439622 | 0.81 | GART (0.48) | GARTDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL9439574 | 0.80 | GART (0.62) | GARTDHFRFOLR2FOLR1SLC19A1 | |
| SCHEMBL9042885 | 0.80 | GART (0.48) | GARTDHFRTYMSFOLR2FOLR1 | |
| SCHEMBL9225937 | 0.79 | DHFR (0.40) | GARTDHFRTYMSFOLR2FOLR1 | |
| SCHEMBL9439711 | 0.79 | GART (0.49) | GARTDHFRFOLR1 | |
| SCHEMBL9439570 | 0.79 | GART (0.58) | GARTDHFRFOLR2FOLR1SLC19A1 | |
| SCHEMBL9041616 | 0.78 | GART (0.54) | GARTTYMSFOLR1 | |
| SCHEMBL9439698 | 0.78 | GART (0.48) | GARTDHFRFOLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0400562-B1 | Pyrrolopyrimidines, their production and use as tumoricidal agents | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-08-21 | — | — | EP | disclosed |
| EP-0400562-A1 | Pyrrolopyrimidines, their production and use as tumoricidal agents | Takeda Chemical Industries, Ltd. (JP) | 1990-12-05 | — | — | EP | disclosed |