Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 16/20 | 0.64 |
| ▸ | ATIC | P31939 | 1/20 | 0.64 |
| ▸ | DHODH | Q02127 | 2/20 | 0.47 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215453 | 0.88 | GART (0.52) | GARTATICDHODHRARB | |
| SCHEMBL9794867 | 0.84 | GART (0.66) | GARTATIC | |
| SCHEMBL9688625 | 0.83 | GART (0.55) | GARTATIC | |
| SCHEMBL9794840 | 0.83 | GART (0.66) | GARTATIC | |
| SCHEMBL7609762 | 0.80 | GART (0.66) | GARTATIC | |
| Dideazaacyclotetrahydrofolic Acid SCHEMBL14469101 | 0.79 | GART (1.00) | GARTATIC | |
| SCHEMBL7257720 | 0.77 | GART (0.49) | GARTATIC | |
| SCHEMBL7612737 | 0.77 | GART (0.65) | GARTATIC | |
| SCHEMBL9338914 | 0.77 | CYP2D6 (0.56) | RARB | |
| SCHEMBL5499213 | 0.77 | GART (0.78) | GARTATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722440-A1 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |
| EP-0722440-A4 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | LILLY CO ELI (US) | 1996-06-04 | — | — | EP | disclosed |
| US-5426110-A | Inhibiting dihydrofolate reductase in mammals and treating susceptible reoplasms | ELI LILLY AND COMPANY (US) | 1995-06-20 | — | — | US | disclosed |
| WO-1995009845-A1 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1995-04-13 | — | — | WO | disclosed |