Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 1/20 | 0.52 |
| ▸ | ATIC | P31939 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | RARB | P10826 | 6/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RARA | P10276 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TYMS | P04818 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038667 | 0.88 | GART (0.64) | GARTATICDHODHRARB | |
| SCHEMBL9036613 | 0.77 | NPSR1 (0.49) | KMT2AMEN1ALDH1A1RARBNPSR1 | |
| SCHEMBL22587286 | 0.75 | KMT2A (0.59) | GARTATICMAPK1KMT2AMEN1 | |
| SCHEMBL7609762 | 0.74 | GART (0.66) | GARTATICTYMS | |
| SCHEMBL512553 | 0.73 | NPSR1 (0.58) | MAPK1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9794867 | 0.72 | GART (0.66) | GARTATICKMT2AALDH1A1MAPT | |
| SCHEMBL7846955 | 0.72 | TYMS (0.66) | GARTATICTYMS | |
| SCHEMBL9794840 | 0.72 | GART (0.66) | GARTATICMAPT | |
| SCHEMBL9688625 | 0.72 | GART (0.55) | GARTATIC | |
| SCHEMBL371605 | 0.72 | RARB (0.71) | KMT2AMEN1ALDH1A1RARBRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5426110-A | Inhibiting dihydrofolate reductase in mammals and treating susceptible reoplasms | ELI LILLY AND COMPANY (US) | 1995-06-20 | — | — | US | disclosed |
| WO-1995009845-A1 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1995-04-13 | — | — | WO | disclosed |