Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 11/20 | 0.66 |
| ▸ | ATIC | P31939 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9794864 | 0.86 | GART (0.59) | GARTATICALDH1A1KMT2ADHFR | |
| SCHEMBL9038667 | 0.84 | GART (0.64) | GARTATIC | |
| SCHEMBL9794840 | 0.82 | GART (0.66) | GARTATICMAPT | |
| SCHEMBL9794911 | 0.80 | GART (1.00) | GARTATIC | |
| SCHEMBL9688625 | 0.80 | GART (0.55) | GARTATIC | |
| SCHEMBL9794843 | 0.75 | GART (0.73) | GARTATICDHFR | |
| SCHEMBL7257720 | 0.74 | GART (0.49) | GARTATIC | |
| SCHEMBL5499213 | 0.74 | GART (0.78) | GARTATIC | |
| SCHEMBL9215453 | 0.72 | GART (0.52) | GARTATICALDH1A1MAPTKMT2A | |
| SCHEMBL9794872 | 0.71 | GART (0.58) | GARTATICALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409382-A1 | Glutamic acid derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-01-23 | — | — | EP | disclosed |
| US-4971973-A | Antitumor agents from polyglutamic acid modified with n- 4- 3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl!propoxyl!benzoyl -glutamic acid | BURROUGHS WELLCOME CO. (US) | 1990-11-20 | — | — | US | disclosed |