Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | FDPS | P14324 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038722 | 1.00 | MAPT (0.43) | MAPTCYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL9599085 | 0.86 | GAA (0.33) | MAPTCYP1A2CYP2C19CYP2D6MAPK1 | |
| SCHEMBL9596670 | 0.81 | HTT (0.46) | MAPTCYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL9597473 | 0.81 | MAPT (0.41) | MAPTCYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL9595515 | 0.79 | MAPT (0.48) | MAPTCYP1A2CYP2C19RAB9ANPC1 | |
| SCHEMBL9599145 | 0.78 | PPIA (0.43) | — | |
| SCHEMBL9595934 | 0.76 | KMT2A (0.45) | MAPTRAB9ANPC1KDM4EL3MBTL1 | |
| SCHEMBL9594788 | 0.74 | RAB9A (0.39) | MAPTRAB9ANPC1KDM4EHTT | |
| SCHEMBL9603546 | 0.74 | KMT2A (0.41) | MAPTRAB9ANPC1KDM4EFDPS | |
| SCHEMBL10993495 | 0.73 | GAA (0.32) | MAPTKMT2AGAAMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385634-B1 | Process for producing pyrido[1,2-a] pyrimidine derivative | WAKO PURE CHEM IND LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| WO-1993016076-A1 | 3-(1H^_-TETRAZOL-5-YL)-4H^_-PYRIDO[1,2-A^_]PYRIMIDINE-4-ONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND THE PREPARATION THEREOF | CHINOIN GYÓGYSZER- ÉS VEGYÉSZETI TERMÉKEK GYÁRA RT. (HU) | 1993-08-19 | — | — | WO | disclosed |
| WO-1993016070-A1 | 3-(PYRIDYLAMINO)-2-(1H^_-TETRAZOL-5-YL)-ACRYLNITRILES AND A PROCESS FOR THE PREPARATION THEREOF | CHINOIN GYÓGYSZER- ÉS VEGYÉSZETI TERMÉKEK GYÁRA RT. (HU) | 1993-08-19 | — | — | WO | disclosed |
| US-5081243-A | Process for producing 3-tetrazolyl pyrido[1,2-a]pyrimidine derivatives | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1992-01-14 | — | — | US | disclosed |
| EP-0385634-A2 | Process for producing pyrido[1,2-a] pyrimidine derivative | WAKO PURE CHEMICAL INDUSTRIES LTD (JP) | 1990-09-05 | — | — | EP | disclosed |