Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | ME2 | P23368 | 6/20 | 0.39 |
| ▸ | ME1 | P48163 | 6/20 | 0.39 |
| ▸ | ME3 | Q16798 | 6/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12362740 | 0.90 | TDP1 (0.41) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL9041528 | 0.81 | DRD2 (0.51) | MAPTALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL27545139 | 0.80 | MAPT (0.55) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL11070043 | 0.75 | MAPT (0.62) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL7041242 | 0.74 | MAPT (0.68) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL17664675 | 0.73 | RGS4 (0.47) | KDM4EALDH1A1LMNASMN1; SMN2PKM | |
| SCHEMBL526167 | 0.73 | ALDH1A1 (0.63) | MAPTKDM4EALDH1A1LMNAGAA | |
| SCHEMBL22349820 | 0.72 | GSK3A (0.44) | KDM4EHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7133435 | 0.71 | GSK3A (0.48) | KDM4EALDH1A1LMNASMN1; SMN2PKM | |
| SCHEMBL9665027 | 0.70 | MAPT (0.62) | MAPTKDM4EALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0402989-B1 | Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones | JANSSEN PHARMACEUTICA NV (BE) | 1996-04-03 | — | — | EP | disclosed |
| US-5075309-A | For prevention and treatment of fungal diseases in mammals | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-24 | — | — | US | disclosed |
| EP-0402989-A2 | Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-12-19 | — | — | EP | disclosed |