Sugi Predict

Sugi Predict / Compounds / SCHEMBL526167

SCHEMBL526167

SCHEMBL526167

CN1CCN(c2ccc(O)cc2)CC1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.63
▸ KDM4E B2RXH2 3/20 0.63
▸ MAPT P10636 3/20 0.63
▸ GAA P10253 3/20 0.63
▸ KMT2A Q03164 2/20 0.63
▸ ADRA2C P18825 1/20 0.63
▸ GFER P55789 1/20 0.63
▸ PTK2B Q14289 1/20 0.63
▸ ESR2 Q92731 1/20 0.63
▸ PKM P14618 1/20 0.62
▸ FYN P06241 2/20 0.55
▸ CHKA P35790 1/20 0.55
▸ SIRT6 Q8N6T7 1/20 0.53
▸ LMNA P02545 2/20 0.53
▸ NPC1 O15118 1/20 0.53
▸ TP53 P04637 1/20 0.53
▸ RAB9A P51151 1/20 0.53
▸ SMN1; SMN2 Q16637 1/20 0.53
▸ ESR1 P03372 2/20 0.52
▸ ESRRG P62508 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7041242 0.88 MAPT (0.68) ALDH1A1KDM4EMAPTGAAKMT2A
SCHEMBL10498349 0.82 MAPT (0.62) ALDH1A1KDM4EMAPTGAAKMT2A
SCHEMBL7106841 0.81 KDM4E (0.61) ALDH1A1KDM4EMAPTGAAKMT2A
SCHEMBL4649484 0.81 HTR3A (0.69) ALDH1A1KDM4EMAPTGAAKMT2A
SCHEMBL30459588 0.80 ESRRG (0.65) ALDH1A1MAPTKMT2AADRA2CESR2
SCHEMBL12333906 0.79 NPC1 (0.80) KDM4EMAPTKMT2ALMNANPC1
SCHEMBL15489560 0.79 MAPT (0.65) ALDH1A1KDM4EMAPTGAAKMT2A
SCHEMBL81814 0.79 MAPT (0.65) ALDH1A1KDM4EMAPTGAAKMT2A
SCHEMBL8931737 0.79 DRD4 (0.67) ALDH1A1KDM4EMAPTGAAKMT2A
SCHEMBL657027 0.78 ALDH1A1 (0.57) ALDH1A1KDM4EMAPTGAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109715632-A Macrocyclic indole derivatives 拜尔公开股份有限公司 2019-05-03 — — CN claimed
EP-1727782-B1 METHOD OF PRODUCING AMINOPHENOL COMPOUNDS OTSUKA PHARMA CO LTD (JP) 2012-08-22 — — EP claimed
US-7750156-B2 Method of producing aminophenol compounds OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2010-07-06 — — US claimed
CN-100478325-C Preparation method for aminophenol compound OTSUKA PHARMA CO LTD (JP) 2009-04-15 — — CN claimed
US-20070219374-A1 Method of Producing Aminophenol Compounds OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-09-20 — — US claimed
CN-1938261-A Preparation method for aminophenol compound OTSUKA PHARMA CO LTD (JP) 2007-03-28 — — CN claimed
EP-1727782-A1 METHOD OF PRODUCING AMINOPHENOL COMPOUNDS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-12-06 — — EP claimed
WO-2005092832-A1 METHOD OF PRODUCING AMINOPHENOL COMPOUNDS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2005-10-06 — — WO claimed
CN-116041300-B 2, 2-Dimethyl benzopyran derivative and preparation method and application thereof 沈阳药科大学 2024-04-26 — — CN disclosed
WO-2024054591-A1 RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2024-03-14 — — WO disclosed
US-20230373939-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2023-11-23 — — US disclosed
US-20230373935-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS, SAN DIEGO 2023-11-23 — — US disclosed
US-20230373935-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS, SAN DIEGO 2023-11-23 — — US disclosed
US-20230373939-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2023-11-23 — — US disclosed
US-20020137742-A1 Benzenesulfonamide compounds LAVIELLE GILBERT (FR) 2002-09-26 — — US disclosed
EP-1118610-B1 Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them SERVIER LAB (FR) 2002-08-21 — — EP disclosed
US-20010009915-A1 New benzenesulfonamide compounds LES LABORATOIRES SERVIER (FR) 2001-07-26 — — US disclosed
EP-1118610-A1 Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 2001-07-25 — — EP disclosed
US-5648368-A ANTICOAGULANTS MERCK & CO., INC. (US) 1997-07-15 — — US disclosed
WO-1994012181-A1 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1994-06-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230373935-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR, SCNN1G, SCNN1B ALDH1A1 3992/4885KDM4E 4141/4885MAPT 4864/4885
US-20070219374-A1 Method of Producing Aminophenol Compounds PAH, CYP1A1, CYP1B1 ALDH1A1 199/4885KDM4E 791/4885MAPT 4188/4885
US-20010009915-A1 New benzenesulfonamide compounds CNR1, CNR2, HTR1A ALDH1A1 905/4885KDM4E 2862/4885MAPT 4844/4885
US-20230373939-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR, SCNN1G, SCNN1B ALDH1A1 3668/4885KDM4E 4303/4885MAPT 4872/4885
US-20020137742-A1 Benzenesulfonamide compounds CNR1, CNR2, HTR1A ALDH1A1 1143/4885KDM4E 2685/4885MAPT 4809/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.